About Us!
What is GTEx Mex?
- The Genotype Tissue Expression of Mexicans (GTEXMex) is a collaborative research project created to collect multiple tissue samples from donors to study their gene expression profiles and genetic regulation to better understand diseases.
- By the joint effort of genomic medicine researchers and clinical pathologists, the first human tissue atlas of Mexicans will be created.
- This atlas will function as a tool for researchers and clinicians around the world to study the genetic regulation of gene expression in tissues such as the heart, lungs, liver, skin, pancreas, adipose tissue, and many more.
Why GTEx Mex?
- Most of the genomic findings have not been translated into functional mechanisms that explain their role in disease development.
- The exploration of underrepresented populations in genomic studies will allow the generalization of the findings, the generation of new knowledge, and the creation of better predictive, preventive, diagnostic, and therapeutic tools.
- This project will bridge the gap in minority populations in translational medicine and their inequitable access to health.
How GTEx Mex Works
- The project will be created from the donation of samples of tissues from deceased Mexican individuals. The samples will be taken by the clinical pathologists during a procedure of hospital necropsy, with the consent of their relatives.
- The DNA from each individual will be genotyped to assess for genetic variation, and from each tissue, the RNA will be isolated to analyze their expression profiles thoroughly. We will search for the genetic variants that correlate with changes in gene expression to identify expression quantitative trait loci (eQTLs).
- We will explore the dynamics of the expression patterns and eQTLS for each tissue, the differences and similarities between the other tissues, and between the different populations. The findings will be associated with the diseases that afflict the Mexican population. Additionally, each tissue will be subjected to a histopathological review, and its digitalized histopathological image will be available. All these findings will be freely accessible through this portal.
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We're looking for passionate researchers to contribute to this groundbreaking project
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